Immunoglobulin M and G antibody responses and persistence of these antibodies in adults after vaccination with a combined meningococcal group A and group C polysaccharide vaccine.

Infection and immunity ·Vol. 37 ·No. 2 ·1982-08-00 ·Pages 579-85

Beuvery EC, Leussink AB, Van Delft RW, Tiesjema RH, Nagel J

Abstract

Adult volunteers were injected with a combined meningococcal group A and group C polysaccharide vaccine. Immunoglobulin M (IgM) and IgG antibody levels against both polysaccharides were measured in serum samples taken 14 days as well as 3 years after vaccination. For both group A and group C polysaccharides, the IgM and IgG antibody levels at 14 days postvaccination were positively related. The IgM-to-IgG antibody ratio at 14 days postvaccination was an indicator for the persistence of both IgM and IgG antibodies during the next 3 years; a high ratio meant a short persistence, whereas a low ratio was associated with a long persistence.

MeSH Terms

Adult Bacterial Vaccines/administration & dosage,immunology Dose-Response Relationship, Immunologic Humans Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Immunoglobulins/biosynthesis Neisseria meningitidis/classification,immunology Polysaccharides, Bacterial/administration & dosage,classification,immunology Time Factors Vaccination

Chemicals

Bacterial Vaccines Immunoglobulin G Immunoglobulin M Immunoglobulins Polysaccharides, Bacterial

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Beuvery E C

Leussink A B

Van Delft R W

Tiesjema R H

Nagel J

References (22)

22 references, click to expand

Secondary IgG responses to type 3 pneumococcal polysaccharide. III. T cell requirement for development of B memory cells.
Eur J Immunol. 1977 Nov;7(11):775-81 PMID: 22439
Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland.
Pediatrics. 1977 Nov;60(5):730-7 PMID: 335348
Vaccines for the prevention of encapsulated bacterial diseases: current status, problems and prospects for the future.
Immunochemistry. 1978 Nov;15(10-11):839-54 PMID: 372096
The influence of T cells on the initiation and expression of immunological memory.
Immunology. 1979 Oct;38(2):265-74 PMID: 389782
Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates.
J Exp Med. 1980 Aug 1;152(2):361-76 PMID: 6967514
Persistence of antibodies in human subjects injected with pneumococcal polysaccharides.
J Immunol. 1950 Nov;65(5):535-41 PMID: 14794919
Properties of the major component of a peptic digest of rabbit antibody.
Science. 1960 Dec 9;132(3441):1770-1 PMID: 13729245
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.
Biochem J. 1959 Sep;73:119-26 PMID: 14434282
Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers.
J Exp Med. 1969 Jun 1;129(6):1367-84 PMID: 4977283
Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharides at ehe cellular level.
J Immunol. 1969 Dec;103(6):1342-8 PMID: 4391281
Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response.
Immunology. 1971 Apr;20(4):469-80 PMID: 4396488
Enteric bacteria cross-reactive with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and 3.
Infect Immun. 1972 Nov;6(5):651-6 PMID: 4118016
The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyl-lysine-substituted pneumococcal polysaccharide (SIII) and levan.
Eur J Immunol. 1974 May;4(5):370-7 PMID: 4153121
Role of T lymphocytes in the humoral immune response. I. Proliferation of B lymphocytes in thymus-deprived mice.
J Immunol. 1974 Nov;113(5):1438-45 PMID: 4138070
Regulatory role of T cells in IgG antibody formation and immune memory to type III Pneumococcal polysaccharide.
J Immunol. 1974 Dec;113(6):1909-20 PMID: 4154347
Peroxidase-labeled antibody. A new method of conjugation.
J Histochem Cytochem. 1974 Dec;22(12):1084-91 PMID: 4443551
Induction of primary and inhibition of secondary antibody response to hapten by hapten conjugates of type III pneumococcal polysaccharide.
Cell Immunol. 1975 Feb;15(2):321-35 PMID: 234300
Clinical evaluation of group A and group C meningococcal polysaccharide vaccines in infants.
J Clin Invest. 1975 Dec;56(6):1536-47 PMID: 1202084
Reliability of the enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of Trichinella spiralis infections in conventionally raised pigs.
J Immunol Methods. 1976;10(1):67-83 PMID: 1254975
Cross-antigenicity and immunogenicity between capsular polysaccharides of group C Neisseria meningitidis and of Escherichia coli K92.
J Infect Dis. 1977 Jan;135(1):94-104 PMID: 64575
Persistence of antibody following immunization of children with groups A and C meningococcal polysaccharide vaccines.
Pediatrics. 1977 Nov;60(5):673-80 PMID: 411104
The regulation of the immune response of mice to Haemophilus influenzae type b capsular polysaccharide.
Immunology. 1978 Jan;34(1):149-56 PMID: 75178

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.37.2.579-585.1982

Published

1982-08-00

Pages

579-85

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347572

Subset

External Links

PubMed source DOI: 10.1128/iai.37.2.579-585.1982 PMC Full Text View journal details

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Immunoglobulin M and G antibody responses and persistence of these antibodies in adults after vaccination with a combined meningococcal group A and group C polysaccharide vaccine.

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