Effect of carbon dioxide and pH on susceptibility of Bacteroides fragilis group to erythromycin.

Antimicrobial agents and chemotherapy ·Vol. 19 ·No. 2 ·1981-02-00 ·Pages 335-6

Hansen SL, Swomley P, Drusano G

Abstract

We examined the effects of pH and incubation in a CO(2)-containing atmosphere on the activity of erythromycin against 81 strains of the Bacteroides fragilis group. A striking reduction in erythromycin activity was noted when the pH decreased below 7.0 and when the organisms were incubated with CO(2).

MeSH Terms

Bacteroides fragilis/drug effects Carbon Dioxide/pharmacology Erythromycin/pharmacology Hydrogen-Ion Concentration Microbial Sensitivity Tests

Chemicals

Carbon Dioxide Erythromycin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hansen S L

Swomley P

Drusano G

References (9)

9 references, click to expand

Collaborative evaluation of a proposed reference dilution method of susceptibility testing of anaerobic bacteria.
Antimicrob Agents Chemother. 1979 Oct;16(4):495-502 PMID: 518079
Variation in susceptibility patterns of species within the Bacteroides fragilis group.
Antimicrob Agents Chemother. 1980 Apr;17(4):686-90 PMID: 7396458
The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro.
J Clin Pathol. 1970 Apr;23(3):254-8 PMID: 5310276
The susceptibility of Bacteroides fragilis to 24 antibiotics.
J Infect Dis. 1972 Mar;125(3):295-9 PMID: 4335792
Susceptibility of anaerobic bacteria to ten antimicrobial agents.
Antimicrob Agents Chemother. 1978 Sep;14(3):371-6 PMID: 708014
Effect of culture medium and carbon dioxide concentration on growth of anaerobic bacteria commonly encountered in clinical specimens.
Appl Microbiol. 1974 Jun;27(6):1098-104 PMID: 4364610
Susceptibility of anaerobic bacteria to 23 antimicrobial agents.
Antimicrob Agents Chemother. 1976 Oct;10(4):736-52 PMID: 984809
Synergistic action of erythromycin and cefamandole against Bacteroides fragilis subsp. fragilis.
Antimicrob Agents Chemother. 1977 May;11(5):813-6 PMID: 879736
Effect of several components of anaerobic incubation on antibiotic susceptibility test results.
Antimicrob Agents Chemother. 1972 May;1(5):433-40 PMID: 4597114

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.19.2.335

Published

1981-02-00

Pages

335-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC181423

Subset

External Links

PubMed source DOI: 10.1128/AAC.19.2.335 PMC Full Text View journal details

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Effect of carbon dioxide and pH on susceptibility of Bacteroides fragilis group to erythromycin.

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