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PMID: 6813318 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Heme inhibition of ferrisiderophore reductase in Bacillus subtilis.

Journal of bacteriology ·Vol. 152 ·No. 2 ·1982-11-00 ·Pages 943-5

Lodge JS, Gaines CG, Arceneaux JE, Byers BR

Abstract

Heme was a noncompetitive inhibitor (apparent K(i) and K'(i) = 0.043 mM) of a ferrisiderophore reductase purified from Bacillus subtilis; protoporphyrin IX had no effect. The cellular level of heme may partly regulate the function of this reductase to yield a controlled flow of iron into metabolism.

MeSH Terms

Bacillus subtilis/enzymology Heme/pharmacology Kinetics NADH, NADPH Oxidoreductases Oxidoreductases/antagonists & inhibitors Structure-Activity Relationship

Chemicals

Heme Oxidoreductases NADH, NADPH Oxidoreductases ferrisiderophore reductase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lodge J S

Gaines C G

Arceneaux J E

Byers B R

References (15)

15 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.152.2.943-945.1982

Published

1982-11-00

Pages

943-5

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC221558

Subset

Grants

NCRR NIH HHS · 5 S07 RR05386 · United States

NIGMS NIH HHS · GM 23778 · United States

External Links

PubMed source DOI: 10.1128/jb.152.2.943-945.1982 PMC Full Text View journal details

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Heme inhibition of ferrisiderophore reductase in Bacillus subtilis.

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