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PMID: 6813376 Published · ppublish English Journal Article

Subdivision of Mycobacterium tuberculosis into five variants for epidemiological purposes: methods and nomenclature.

The Journal of hygiene ·Vol. 89 ·No. 2 ·1982-10-00 ·Pages 235-42

Collins CH, Yates MD, Grange JM

Abstract

Virulent strains of Mycobacterium tuberculosis isolated from humans are divisible into five variants by using four tests: oxygen requirement (aerobic or microaerophilic), nitrate reductase activity, susceptibility to pyrazinamide (60 micrograms/ml) and susceptibility to thiophene-2-carboxylic acid hydrazide (5 micrograms/ml). The five variants are referred to as Classical human, Asian human, bovine, African I and African II. The relation of these variants to previously described types is discussed. This simple division has been shown to be useful in epidemiological studies.

MeSH Terms
Humans Microbial Sensitivity Tests Microbiological Techniques Mycobacterium tuberculosis/classification,drug effects,isolation & purification Nitrate Reductases/metabolism Oxygen Consumption Pyrazinamide/pharmacology Racial Groups Thiophenes/pharmacology
Chemicals
Thiophenes thiophene-2-carboxylic acid hydrazide Pyrazinamide Nitrate Reductases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Collins C H
Yates M D
Grange J M
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22 references, click to expand
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Article Info
Journal
The Journal of hygiene
Abbr.
J Hyg (Lond)
ISSN
0022-1724
DOI
10.1017/s0022172400070765
Published
1982-10-00
Pages
235-42
Language
English
Region
England
NLM ID
0375374
PMCID
PMC2134208
Subset
IM
External Links
PubMed source DOI: 10.1017/s0022172400070765 PMC Full Text View journal details
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