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PMID: 6817330 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A theory of allelic and isotypic exclusion for immunoglobulin genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 22 ·1982-11-00 ·Pages 6976-8

Wabl M, Steinberg C

Abstract

Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the "H chain toxicity" effect.

MeSH Terms

Alleles Animals B-Lymphocytes/immunology Genes Immunoglobulin Heavy Chains/genetics Immunoglobulin Light Chains/genetics Immunoglobulins/genetics

Chemicals

Immunoglobulin Heavy Chains Immunoglobulin Light Chains Immunoglobulins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wabl M

Steinberg C

References (12)

12 references, click to expand

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Proc Natl Acad Sci U S A. 1980 Apr;77(4):1937-41 PMID: 6769117
Immunoglobulin chain loss in hybridoma lines.
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2197-9 PMID: 6769123
Allelic exclusion and nonproductive immunoglobulin gene rearrangements.
Cell. 1981 Apr;24(1):1-3 PMID: 6972259
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Proc Natl Acad Sci U S A. 1982 Jan;79(2):606-7 PMID: 6952212
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.79.22.6976

Published

1982-11-00

Pages

6976-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC347257

Subset

External Links

PubMed source DOI: 10.1073/pnas.79.22.6976 PMC Full Text View journal details

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