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PMID: 6818899 Published · ppublish English Journal Article

In vitro evaluation of N-formimidoyl thienamycin (MK0787) combined with amikacin against gram-negative bacilli and Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 22 ·No. 6 ·1982-12-00 ·Pages 1064-6

Díez Enciso M, Mateos Lindemann M, Gutiérrez Altés A

Abstract

The in vitro synergistic activity of N-formimidoyl thienamycin and amikacin was determined against gentamicin-resistant enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus. N-Formimidoyl thienamycin showed synergism with amikacin against 19 of the gentamicin-resistant strains, 14 of the 49 strains of S. aureus, and only 1 strain of the 46 P. aeruginosa isolates.

MeSH Terms
Amikacin/pharmacology Anti-Bacterial Agents/pharmacology Bacteria/drug effects Drug Resistance, Microbial Drug Synergism Enterobacteriaceae/drug effects Gentamicins/pharmacology Imipenem Kanamycin/analogs & derivatives Pseudomonas aeruginosa/drug effects Staphylococcus aureus/drug effects Thienamycins/pharmacology
Chemicals
Anti-Bacterial Agents Gentamicins Thienamycins Kanamycin Imipenem Amikacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Díez Enciso M
Mateos Lindemann M
Gutiérrez Altés A
References (11)
11 references, click to expand
  1. In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin.
    Antimicrob Agents Chemother. 1980 Oct;18(4):557-61 PMID: 6934707
  2. MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.
    Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000 PMID: 6931549
  3. Comparison of techniques for measurement of in vitro antibiotic synergism.
    J Infect Dis. 1979 Oct;140(4):629-33 PMID: 390067
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    Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 PMID: 4208895
  5. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.
    J Antibiot (Tokyo). 1979 Jan;32(1):1-12 PMID: 761989
  6. Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains.
    Antimicrob Agents Chemother. 1980 Nov;18(5):837-8 PMID: 6969580
  7. Antibiotic combinations: the clinical relevance of synergy and antagonism.
    Medicine (Baltimore). 1978 Mar;57(2):179-95 PMID: 202836
  8. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.
    Antimicrob Agents Chemother. 1982 Jan;21(1):180-7 PMID: 6979306
  9. Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12.
    Antimicrob Agents Chemother. 1977 Sep;12(3):406-9 PMID: 334066
  10. In vitro activity of N-formimidoyl thienamycin (MK0787).
    Antimicrob Agents Chemother. 1980 Oct;18(4):642-4 PMID: 6934708
  11. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.
    J Biol Chem. 1954 Jun;208(2):477-88 PMID: 13174557
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.22.6.1064
Published
1982-12-00
Pages
1064-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC185722
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.22.6.1064 PMC Full Text View journal details
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