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PMID: 6821126 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 19 ·1982-10-00 ·Pages 5961-5

Carpenter AT

Abstract

Recombination-defective mutants at two loci that are known to decrease drastically the frequency of meiotic crossing-over do not decrease the frequency of gene conversion at the rosy locus. mei-9 mutant alleles produce frequent postmeiotic segregants manifested as mosaic progeny whereas controls and mei-218 mutants produce none. It is concluded that (i) recombination in Drosophila involves a biparental DNA intermediate and (ii) correction of heteroduplex DNA or recognition of biparental DNA or both is necessary, but not sufficient, for this intermediate to result in crossing-over of flanking markers. It is therefore likely, at least in Drosophila, that the isomerization step in Meselson-Radding type molecular models of recombination is under genetic control.

MeSH Terms
Alleles Animals Crosses, Genetic Crossing Over, Genetic DNA Repair Drosophila melanogaster/genetics Female Gene Conversion Genes Male Mutation Recombination, Genetic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Carpenter A T
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19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.19.5961
Published
1982-10-00
Pages
5961-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347031
Subset
IM
Grants
NIGMS NIH HHS · GM26200 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.19.5961 PMC Full Text View journal details
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