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PMID: 6828388 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.

Nucleic acids research ·Vol. 11 ·No. 5 ·1983-03-11 ·Pages 1589-99

Fisher EF, Caruthers MH

Abstract

Triarylmethyl groups having different colors but similar chemical reactivities in acid were examined as potential aids for monitoring the stepwise addition of mononucleotides to a deoxyoligonucleotide. The successful application of these protecting groups to deoxyoligonucleotide synthesis on polymer supports was demonstrated.

MeSH Terms
Color Indicators and Reagents Polydeoxyribonucleotides/chemical synthesis Spectrophotometry Structure-Activity Relationship
Chemicals
Indicators and Reagents Polydeoxyribonucleotides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fisher E F
Caruthers M H
References (5)
5 references, click to expand
  1. DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping.
    Nucleic Acids Res. 1974 Mar;1(3):331-53 PMID: 10793670
  2. Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.
    Nucleic Acids Res. 1980 Mar 11;8(5):1081-96 PMID: 7443540
  3. Synthesis of oligodeoxyribonucleotides on silica gel support.
    Nucleic Acids Res. 1981 Jun 25;9(12):2807-17 PMID: 6269061
  4. Ultrafast sequencing of oligodeoxyribonucleotides by FAB-mass spectrometry.
    Nucleic Acids Res. 1982 Aug 11;10(15):4671-8 PMID: 7133994
  5. Recent developments in the chemical synthesis of polynucleotides.
    Nucleic Acids Res. 1982 Nov 11;10(21):6553-70 PMID: 6757865
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.5.1589
Published
1983-03-11
Pages
1589-99
Language
English
Region
England
NLM ID
0411011
PMCID
PMC325818
Subset
IM
Grants
NIGMS NIH HHS · 1 KO4 GM00076 · United States
NIGMS NIH HHS · GM21120 · United States
NIGMS NIH HHS · GM25680 · United States
External Links
PubMed source DOI: 10.1093/nar/11.5.1589 PMC Full Text View journal details
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