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PMID: 6832286 Published · ppublish English Comparative Study Journal Article

Human lactotransferrin: molecular, functional and evolutionary comparisons with human serum transferrin and hen ovotransferrin.

Experientia ·Vol. 39 ·No. 2 ·1983-02-15 ·Pages 135-41

Mazurier J, Metz-Boutigue MH, Jollès J, Spik G, Montreuil J, Jollès P

Abstract

In this review article, human lactotransferrin is compared to human serum transferrin and hen ovotransferrin. For the first time the possibility of a 6-fold internal homology of the transferrins is raised: a scheme in which 6 domains are defined is reported; two of them with the highest homology seem to be implicated in the 2 iron binding sites of each transferrin. The location of the disulfide bridges of the 3 transferrins and of their prosthetic sugar groups is discussed: some not yet described half-cystine containing lactotransferrin peptides are indicated.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Animals Binding Sites Biological Evolution Conalbumin Cystine/analysis Disulfides/metabolism Egg Proteins Female Humans Iron/metabolism Lactoferrin Lactoglobulins Polysaccharides/analysis Protein Conformation Transferrin/analysis
Chemicals
Amino Acids Disulfides Egg Proteins Lactoglobulins Polysaccharides Transferrin Conalbumin Cystine Iron Lactoferrin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mazurier J
Metz-Boutigue M H
Jollès J
Spik G
Montreuil J
Jollès P
References (25)
25 references, click to expand
  1. The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.
    J Biol Chem. 1975 Mar 25;250(6):2182-8 PMID: 803968
  2. Structural relatedness between human lactotransferrin and human ceruloplasmin.
    FEBS Lett. 1981 Sep 28;132(2):239-42 PMID: 7297694
  3. Location of the carbohydrate groups of ovomucoid.
    Biochem J. 1976 Nov;159(2):335-45 PMID: 999651
  4. The formation of iron-binding fragments of hen ovotransferrin by limited proteolysis.
    Biochem J. 1974 Sep;141(3):745-52 PMID: 4463961
  5. The identification of protected tyrosine residues in iron-ovotransferrin.
    Biochem J. 1982 Mar 1;201(3):647-51 PMID: 7092815
  6. The complete amino acid sequence of human serum transferrin.
    Proc Natl Acad Sci U S A. 1982 Apr;79(8):2504-8 PMID: 6953407
  7. Enzymatic N-glycosylation of synthetic Asn--X--Thr containing peptides.
    FEBS Lett. 1978 Dec 1;96(1):179-82 PMID: 729783
  8. The primary structure of hen ovotransferrin.
    Eur J Biochem. 1982 Feb;122(2):297-303 PMID: 6895872
  9. Carbohydrate-peptide linkage in glycoproteins.
    Arch Biochem Biophys. 1976 Aug;175(2):410-8 PMID: 958311
  10. Evidence for an internal homology in human lactoferrin structure [proceedings].
    Arch Int Physiol Biochim. 1980 Feb;88(1):B12-B13 PMID: 6155833
  11. Structural studies concerning human lactotransferrin: its relatedness with human serum transferrin and evidence for internal homology.
    Biochimie. 1978 Sep 4;60(5):557-61 PMID: 698294
  12. Chemical modification of the arginines in transferrins.
    Biochemistry. 1978 Mar 21;17(6):1105-9 PMID: 564709
  13. Comparative study of the iron-binding properties of transferrins. Differences in the involvement of histidine residues as revealed by carbethoxylation.
    Eur J Biochem. 1981 Oct;119(3):537-43 PMID: 7308200
  14. The amino acid sequences of cysteic acid-containing peptides from performic acid-oxidized ovotransferrin.
    Biochem J. 1970 Feb;116(3):515-32 PMID: 4907959
  15. Ribosomal protein S1 is the product of a series of contiguous duplications.
    Biosci Rep. 1982 Jun;2(6):405-12 PMID: 7049263
  16. Human transferrin C: the sequence and cystine bridges of the N-terminal region.
    Tex Rep Biol Med. 1978;36:47-61 PMID: 725796
  17. An 88 amino acid long C-terminal sequence of human lactotransferrin.
    FEBS Lett. 1982 Jun 1;142(1):107-10 PMID: 7049727
  18. Evidence for the bilobal nature of diferric rabbit plasma transferrin.
    Nature. 1979 Sep 13;281(5727):157-8 PMID: 471065
  19. Comparative study on histidine modification by diethylpyrocarbonate in human serotransferrin and lactotransferrin.
    FEBS Lett. 1975 Aug 15;56(2):337-40 PMID: 1157951
  20. Prediction of protein conformation.
    Biochemistry. 1974 Jan 15;13(2):222-45 PMID: 4358940
  21. An electron paramagnetic resonance study of the iron and copper complexes of transferrin.
    J Biol Chem. 1968 May 10;243(9):2399-404 PMID: 4296841
  22. Transfer of iron from serum iron-binding protein to human reticulocytes.
    J Clin Invest. 1959 Jan 1;38(1, Part 1):161-85 PMID: 13620780
  23. The complete nucleotide sequence of the chicken ovotransferrin mRNA.
    Eur J Biochem. 1982 Feb;122(2):291-5 PMID: 7060577
  24. Iron binding proteins and influx of iron across the duodenal brush border. Evidence for specific lactotransferrin receptors in the human intestine.
    Biochim Biophys Acta. 1979 Nov 15;588(1):120-8 PMID: 227471
  25. The present state of the human lactotransferrin sequence. Study and alignment of the cyanogen bromide fragments and characterization of N- and C-terminal domains.
    Biochim Biophys Acta. 1981 Sep 29;670(2):243-54 PMID: 6794640
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01958861
Published
1983-02-15
Pages
135-41
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01958861
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