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PMID: 6857247 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.

Science (New York, N.Y.) ·Vol. 220 ·No. 4603 ·1983-06-17 ·Pages 1277-9

Hedgecock EM, Sulston JE, Thomson JN

Abstract

Mutations in two nonessential genes specifically block the phagocytosis of cells programmed to die during development. With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths. Instead, these deaths appear to occur by cell suicide.

MeSH Terms
Animals Autophagy Caenorhabditis/genetics,growth & development Cell Survival DNA/metabolism Female Male Microscopy, Electron Mutation
Chemicals
DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hedgecock E M
Sulston J E
Thomson J N
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.6857247
Published
1983-06-17
Pages
1277-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.6857247 View journal details
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