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PMID: 687772 Published · ppublish English Journal Article

Tension transients in fibrillar muscle fibres as affected by stretch-dependent binding of AMP-PNP: a teinochemical effect?

Biophysics of structure and mechanism ·Vol. 4 ·No. 3 ·1978-07-12 ·Pages 209-22

Kuhn HJ

Abstract

The recovery in tension after release of a fibrillar muscle preparation as well as the fall in tension after restretch was found to be greater in presence of AMP-PNP than in its absence (rigor). The effect of AMP-PNP was concentration-dependent with an optimum at 0.1 mM corresponding to the dissociation constant of AMP-PNP from the myosin heads. This evidence supports the validity of the teinochemical principle which predicts a stretch-dependent AMP-PNP binding. The stiffness calculated per cross bridge was similar to that found by Huxley and Simmons (1971). It was further calculated that only 15% of the cross bridges are in a force-maintaining state in rigor.

MeSH Terms
Actins/metabolism Adenosine Triphosphate/analogs & derivatives Adenylyl Imidodiphosphate/pharmacology Animals Biomechanical Phenomena In Vitro Techniques Muscle Contraction/drug effects Muscle Relaxation/drug effects Muscles/physiology Myofibrils/physiology Myosins/metabolism
Chemicals
Actins Adenylyl Imidodiphosphate Adenosine Triphosphate Myosins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kuhn H J
References (21)
21 references, click to expand
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Article Info
Journal
Biophysics of structure and mechanism
Abbr.
Biophys Struct Mech
ISSN
0340-1057
DOI
10.1007/BF02426086
Published
1978-07-12
Pages
209-22
Language
English
Region
Germany
NLM ID
7502020
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02426086
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