Triiodothyronine-dietary interrelationships in the modulation of brown adipose tissue and liver lipogenesis in the rat.

The influence of diet and triiodothyronine on "in vivo" lipogenesis has been compared in liver and brown adipose tissue of the rat at weaning and in adult life. At both ages studied, hyperthyroidism increases lipogenesis only in the liver. However brown adipose tissue accumulates lipid (probably derived from white adipose tissue) thus helping to explain previous observations of low rates of lipogenesis in this tissue during the late suckling period when thermogenesis is high and plasma triiodothyronine levels rise. Suppression of lipogenesis by dietary polyunsaturated fat in both tissues at both ages studied confirms previous studies on adult animals. Malic enzyme and glucose-6-phosphate dehydrogenase activities correlate well with changes in lipogenesis in brown adipose tissue but not in liver and the hepatic enzymes exhibit a diminished response to dietary and hormonal factors with age.