Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system.

Acute Disease Adjuvants, Immunologic/pharmacology Animals Autoimmune Diseases/etiology,immunology,pathology Bacterial Toxins/pharmacology Brain/metabolism Capillary Permeability/drug effects Dose-Response Relationship, Immunologic Encephalomyelitis/etiology,immunology,pathology Female Histamine Antagonists/pharmacology Hypersensitivity, Delayed/immunology Male Mice Mice, Inbred BALB C Mice, Inbred NZB Muridae Pertussis Vaccine/immunology Spinal Cord/metabolism Vasomotor System/drug effects,immunology Virulence Factors, Bordetella

Adjuvants, Immunologic Bacterial Toxins Histamine Antagonists Pertussis Vaccine Virulence Factors, Bordetella