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PMID: 68924 Published · ppublish English Journal Article

Detection and molecular characterization of the thymus-brain antigen in human brain.

Immunology ·Vol. 33 ·No. 1 ·1977-07-00 ·Pages 101-7

Arndt R, Stark R, Thiele HG

Abstract

Anti-human brain sera were found to contain antibodies reacting with determinants present on murine thymocyte plasma membranes. This determinant is borne by the thymocyte-brain antigen of mouse thymocytes. The non species-specific determinant of the thymocyte-brain system is detectable on the thymocyte-brain antigen of human and mouse brain in comparable amounts. In contrast to these findings, the allogenic Thy-1 and the species-specific determinant of this system were only found on the thymocyte-brain antigen of mouse brain but not on the corresponding antigen of human brain. The molecular weight, Stokes radius and diffusion coefficient of the thymocyte-brain antigen of human and mouse brain are in good accordance with the data estimated for the corresponding antigen of murine thymocytes.

MeSH Terms
Animals Antigens/analysis Brain/immunology Chromatography, Affinity Chromatography, Gel Cytotoxicity Tests, Immunologic Epitopes Humans Mice Organ Specificity T-Lymphocytes/immunology
Chemicals
Antigens Epitopes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Arndt R
Stark R
Thiele H G
References (24)
24 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1977-07-00
Pages
101-7
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445415
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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