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PMID: 6893736 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions.

Nature ·Vol. 288 ·No. 5790 ·1980-12-04 ·Pages 455-9

Isenberg G, Aebi U, Pollard TD

Abstract

A protein has been purified from Acanthamoeba which, like cytochalasin B, caps the end of actin filaments normally favoured for monomer addition and inhibits the interactions of actin filaments. In addition, this 'capping' protein nucleates the polymerization of actin monomers and blocks the annealing of actin filament fragments.

MeSH Terms
Actins/metabolism Amoeba/analysis Animals Carrier Proteins/isolation & purification,metabolism Crystallography Cytoskeleton/metabolism,ultrastructure Gels Gelsolin Macromolecular Substances Microfilament Proteins Molecular Weight
Chemicals
Actins Carrier Proteins Gels Gelsolin Macromolecular Substances Microfilament Proteins brevin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Isenberg G
Aebi U
Pollard T D
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/288455a0
Published
1980-12-04
Pages
455-9
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
NIGMS NIH HHS · GM-26338 · United States
NIGMS NIH HHS · GM27765 · United States
External Links
PubMed source DOI: 10.1038/288455a0 View journal details
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