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PMID: 689684 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids.

Human genetics ·Vol. 43 ·No. 2 ·1978-08-31 ·Pages 119-25

Shows TB, Brown JA, Eddy RL, Byers MG, Haley LL, Cooper ES, Goggin AP

Abstract

A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.

MeSH Terms
Aminopeptidases/genetics Animals Chromosomes, Human, 4-5 Cricetinae Electrophoresis, Starch Gel Genes Genetic Linkage Humans Hybrid Cells Mice
Chemicals
Aminopeptidases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Shows T B
Brown J A
Eddy R L
Byers M G
Haley L L
Cooper E S
Goggin A P
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23 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00293588
Published
1978-08-31
Pages
119-25
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00293588 View journal details
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