Home LiteratureArticle Details
PMID: 689739 Published · ppublish English Journal Article

Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin.

Infection and immunity ·Vol. 21 ·No. 2 ·1978-08-00 ·Pages 655-8

Walker RI, Porvaznik MJ

Abstract

A freeze-fracture technique was used to examine the most apical intercellular junctional complex between intestinal epithelial cells (the tight or occluding junction) in mice after challenge with endotoxin. Some of these junctions were disrupted after challenge and may be a site for leakage of microbial agents from the lumen.

MeSH Terms
Animals Cell Membrane Permeability Endotoxins/toxicity Epithelial Cells Freeze Fracturing Intercellular Junctions Intestines/cytology Mice
Chemicals
Endotoxins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Walker R I
Porvaznik M J
References (14)
14 references, click to expand
  1. Studies on distribution of Escherichia coli endotoxin in mice.
    Proc Soc Exp Biol Med. 1959 Jan;100(1):65-8 PMID: 13634037
  2. Studies with radioactive endotoxin. III. The effect of tolerance on the distribution of radioactivity after intravenous injection of Escherichia coli endotoxin labeled with Cr51.
    J Clin Invest. 1958 Mar;37(3):441-57 PMID: 13513775
  3. Endotoxaemia in man.
    Lancet. 1972 Jun 24;1(7765):1381-5 PMID: 4113578
  4. Endotoxaemia in man.
    Lancet. 1972 Jul 22;2(7769):181 PMID: 4114077
  5. Freeze-etching nomenclature.
    Science. 1975 Oct 3;190(4209):54-6 PMID: 1166299
  6. Structure and function of intercellular junctions.
    Int Rev Cytol. 1974;39:191-283 PMID: 4611943
  7. The escape of endotoxin from the intestine.
    Surg Gynecol Obstet. 1974 Sep;139(3):395-402 PMID: 4605257
  8. On the in vivo clearance and detoxification of endotoxin by lung and liver.
    Ann Surg. 1973 Feb;177(2):159-63 PMID: 4572780
  9. Aseptic endotoxemia in radiation injury and graft-vs-host diesease.
    Radiat Res. 1975 May;62(2):242-9 PMID: 235772
  10. Role of the intestinal flora in clearance and detoxification of circulating endotoxin.
    J Reticuloendothel Soc. 1973 Dec;14(6):513-21 PMID: 4775528
  11. Production of fatal endotoxic shock by vasoactive substances.
    Gastroenterology. 1973 Feb;64(2):285-91 PMID: 4686336
  12. Route of absorption of endotoxin from the intestine in nonseptic shock.
    J Reticuloendothel Soc. 1972 Jun;11(6):535-8 PMID: 5046172
  13. Establishment of tight junctions between epithelial cells.
    Proc Natl Acad Sci U S A. 1975 Jul;72(7):2711-3 PMID: 1058486
  14. Detoxification of endotoxin by perfusion of liver and spleen.
    Proc Soc Exp Biol Med. 1967 Jun;125(2):455-9 PMID: 6028564
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.21.2.655-658.1978
Published
1978-08-00
Pages
655-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422042
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.21.2.655-658.1978 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2