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PMID: 69058 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Immunisation with a polyvalent pneumococcal vaccine. Reduction of adult respiratory mortality in a New Guinea Highlands community.

Lancet (London, England) ·Vol. 1 ·No. 8026 ·1977-06-25 ·Pages 1338-41

Riley ID, Tarr PI, Andrews M, Pfeiffer M, Howard R, Challands P, Jennison G

Abstract

A double-blind controlled trial of a 14-valent pneumococcal polysaccharide vaccine was carried out in 11 958 adults at Tari in the Papua New Guinea Highlands. Pneumococcal infection, confirmed by blood-culture and lung aspirate, was less in the vaccinated group by 84%. Mortality from pneumonia was less by 44%.

MeSH Terms

Adult Antibodies, Bacterial/isolation & purification Bacterial Vaccines/administration & dosage,therapeutic use Clinical Trials as Topic Evaluation Studies as Topic Follow-Up Studies Humans Lung/microbiology New Guinea Nose/microbiology Pneumonia, Pneumococcal/microbiology,mortality,prevention & control Polysaccharides, Bacterial/administration & dosage,therapeutic use Sepsis/microbiology Sputum/microbiology Streptococcus pneumoniae/immunology,isolation & purification

Chemicals

Antibodies, Bacterial Bacterial Vaccines Polysaccharides, Bacterial

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Riley I D

Tarr P I

Andrews M

Pfeiffer M

Howard R

Challands P

Jennison G

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(77)92552-1

Published

1977-06-25

Pages

1338-41

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(77)92552-1 View journal details

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Immunisation with a polyvalent pneumococcal vaccine. Reduction of adult respiratory mortality in a New Guinea Highlands community.

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