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PMID: 6914197 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Equilibration of leucine between the plasma compartment and leucyl-tRNA in the heart, and turnover of cardiac myosin heavy chain.

The Biochemical journal ·Vol. 194 ·No. 1 ·1981-01-15 ·Pages 365-8

Everett AW, Prior G, Zak R

Abstract

By 30min continuous infusion of [3H]leucine into rats, the specific radioactivities of plasma leucine and tissue-free and tRNA-bound leucine in heart were equal. The specific radioactivity of leucyl-tRNA in heart therefore follows a time course identical with that of plasma leucine soon after the start of infusion. The half-life of cardiac myosin heavy chain (5.5 days) was the same as that reported by other investigators who used the pulse-labelling protocol.

MeSH Terms
Animals Female Half-Life Kinetics Leucine/blood,metabolism Myocardium/metabolism Myosins/metabolism RNA, Transfer, Amino Acyl/metabolism Rats
Chemicals
RNA, Transfer, Amino Acyl Myosins Leucine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Everett A W
Prior G
Zak R
References (18)
18 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1940365
Published
1981-01-15
Pages
365-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1162753
Subset
IM
Grants
NHLBI NIH HHS · HL16637 · United States
NHLBI NIH HHS · HL20592 · United States
External Links
PubMed source DOI: 10.1042/bj1940365 PMC Full Text View journal details
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