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PMID: 6925979 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.

Cancer immunology, immunotherapy : CII ·Vol. 13 ·No. 3 ·1982-00-00 ·Pages 149-52

Einhorn S, Jarstrand C

Abstract

The influence of daily intramuscular injections of 3 X 10(6) units of interferon-alpha (IFN-alpha) on the phagocytic activity of peripheral monocytes was studied in 28 tumor patients. One day after initiation of IFN therapy no major change in the capacity of monocytes to ingest yeast particles was observed. After 1 week, 3 months, 6 months, and 9 months of treatment, monocyte phagocytosis had decreased in the majority of the patients tested. In patients where natural killer (NK) cell activity was measured simultaneously with monocyte phagocytosis, a correlation between the degree of enhancement of NK activity and the degree of decrease in monocyte phagocytosis was observed.

MeSH Terms
Adolescent Adult Aged Child Female Humans Interferon Type I/pharmacology Killer Cells, Natural/immunology Male Middle Aged Monocytes/immunology Neoplasms/immunology Phagocytosis/drug effects
Chemicals
Interferon Type I
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Einhorn S
Jarstrand C
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19 references, click to expand
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Article Info
Journal
Cancer immunology, immunotherapy : CII
Abbr.
Cancer Immunol Immunother
ISSN
0340-7004
DOI
10.1007/BF00205379
Published
1982-00-00
Pages
149-52
Language
English
Region
Germany
NLM ID
8605732
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00205379 View journal details
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