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PMID: 6928630 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of an adhesion factor for chondrocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 1 ·1980-01-00 ·Pages 385-8

Hewitt AT, Kleinman HK, Pennypacker JP, Martin GR

Abstract

The attachment of chondrocytes to collagen substrates is stimulated by serum but not by fibronectin. The active material in serum was partially purified and was shown to be a protein by its sensitivity to trypsin and heat and its chromatographic properties. This factor, which we have named chondronectin, is distinct from fibronectin and does not stimulate fibroblast attachment. Because material with similar attachment-enhancing activity is produced by chondrocytes and is extractable from cartilage, chondronectin may be a chondrocyte-specific attachment protein.

MeSH Terms
Animals Blood Cartilage/cytology Cell Adhesion Cell Line Chick Embryo Collagen/metabolism Fibronectins/metabolism
Chemicals
Fibronectins Collagen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hewitt A T
Kleinman H K
Pennypacker J P
Martin G R
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.1.385
Published
1980-01-00
Pages
385-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348275
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.1.385 PMC Full Text View journal details
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