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PMID: 6933470 Published · ppublish English Journal Article

Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 7 ·1980-07-00 ·Pages 4221-5

Neel JV, Satoh C, Hamilton HB, Otake M, Goriki K, Kageoka T, Fujita M, Neriishi S, Asakawa J

Abstract

A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of "proximally exposed" parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of "distally exposed" parents, who had essentially no radiation exposure.

MeSH Terms
Dose-Response Relationship, Radiation Enzymes/genetics Humans Japan Mutation Nuclear Warfare Polymorphism, Genetic Protein Conformation Proteins/genetics
Chemicals
Enzymes Proteins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Neel J V
Satoh C
Hamilton H B
Otake M
Goriki K
Kageoka T
Fujita M
Neriishi S
Asakawa J
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20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.7.4221
Published
1980-07-00
Pages
4221-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349803
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.7.4221 PMC Full Text View journal details
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