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PMID: 6935684 Published · ppublish English Journal Article

Antiviral response elicited by a completely synthetic antigen with built-in adjuvanticity.

Arnon R, Sela M, Parant M, Chedid L

Abstract

In a previous study we demonstrated that antiviral response against the coliphage MS-2 can be elicited by immunization with a synthetic antigen consisting of a conjugate (P2-A -- L) of a synthetic fragment (P2) of the virus coat protein attached to a synthetic polymeric carrier. The antiviral response was induced when the antigen was administered in complete Freund's adjuvant or when it was administered in incomplete adjuvant, provided that a peptidoglycan was covalently attached to it. In the present study we demonstrate the adjuvant effect of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in this system. Immunization with a mixture of MDP and P2-A -- L brought about only slight enhancement in the titer of neutralizing antibodies, as compared to the immunization with P2-A -- L in saline. The best results were achieved when the MDP was chemically conjugated to P2-A -- L. This completely synthetic material, when administered in aqueous solution, yielded highly inactivating antiserum with a titer similar to that obtained with complete Freund's adjuvant in the absence of MDP. MDP-P2-A -- L elicited also a humoral immune response to MDP, but with much lower titer than that induced by complete Freund's adjuvant containing P2-A -- L only. It was also observed that the capacity of MDP-P2-A -- L to increase resistance against infection was more than a 100-fold greater than that of unconjugated MDP.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/immunology Adjuvants, Immunologic Animals Antibodies, Viral/biosynthesis Antibody Formation Antigens, Viral Coliphages/immunology Rabbits Viral Proteins/immunology
Chemicals
Adjuvants, Immunologic Antibodies, Viral Antigens, Viral Viral Proteins Acetylmuramyl-Alanyl-Isoglutamine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Arnon R
Sela M
Parant M
Chedid L
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1980-11-00
Pages
6769-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350370
Subset
IM
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