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PMID: 6937275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human osteosarcoma-derived soluble bone morphogenetic protein.

Clinical orthopaedics and related research ·No. 154 ·1981-00-00 ·Pages 291-5

Bauer FC, Urist MR

Abstract

A bone morphogenetic protein (BMP) fraction obtained from the organic matrix of dentin is extractable from human osteosarcoma. A fresh en-bloc specimen excised from the femur of a 16-year-old boy was extracted with 4 M guanidine hydrochloride. The GuHCl-soluble, water-insoluble protein fraction induced new bone formation when implanted into the thigh muscles of athymic nude mice.

MeSH Terms

Animals Bone Morphogenetic Proteins Bone and Bones/drug effects Cartilage/drug effects Collagen/analysis Femoral Neoplasms/metabolism Growth Substances/pharmacology Humans Hydroxyproline/analysis Male Mice Mice, Nude Neoplasm Proteins/pharmacology Neoplasm Transplantation Osteogenesis Osteosarcoma/metabolism Peptides/analysis Proteins/pharmacology Transplantation, Heterologous

Chemicals

Bone Morphogenetic Proteins Growth Substances Neoplasm Proteins Peptides Proteins Collagen Hydroxyproline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bauer F C

Urist M R

Article Info

Journal

Clinical orthopaedics and related research

Abbr.

Clin Orthop Relat Res

ISSN

0009-921X

Published

1981-00-00

Pages

291-5

Language

English

Region

United States

NLM ID

0075674

Subset

Grants

NIDCR NIH HHS · DEO2103-16 · United States

External Links

PubMed source View journal details

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Human osteosarcoma-derived soluble bone morphogenetic protein.

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