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PMID: 6942423 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human embryonic somatomedin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 5 ·1981-05-00 ·Pages 3175-9

Sara VR, Hall K, Rodeck CH, Wetterberg L

Abstract

A radioreceptor assay utilizing human fetal brain plasma membrane as matrix and somatomedin A as ligand (fetal brain RRA-SMA) was developed. Increased levels of fetal brain RRA-SMA were found in the fetal circulation. The concentration was approximately 4-fold higher in the fetal as compared to the adult human. At birth, values fell within the adult range. In contrast, adult somatomedins determined by somatomedin radioimmunoassay were undetectable in the fetus and below the adult range at birth. Levels of fetal brain RRA-SMA were decreased in fetuses with different clinical disorders. In healthy newborns at cesarean section a significant correlation between serum fetal brain RRA-SMA values and birth weight and length was found. These results indicate the presence of an embryonic somatomedin in humans. The fetal brain RRA-SMA may provide a reliable index of fetal growth.

MeSH Terms
Adult Brain/embryology Brain Chemistry Cell Membrane/analysis Embryo, Mammalian/physiology Female Fetal Blood/analysis Gestational Age Humans Male Pregnancy Radioligand Assay Somatomedins/blood
Chemicals
Somatomedins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sara V R
Hall K
Rodeck C H
Wetterberg L
References (31)
31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.5.3175
Published
1981-05-00
Pages
3175-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319523
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.5.3175 PMC Full Text View journal details
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