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PMID: 6945674 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein.

Science (New York, N.Y.) ·Vol. 214 ·No. 4521 ·1981-11-06 ·Pages 659-60

Epstein EH, Krauss RM, Shackleton CH

Abstract

Plasma cholesterol sulfate concentration is increased in patients with recessive X-linked ichthyosis, a disease in which steroid sulfatase activity is absent. In these patients, cholesterol sulfate is found primarily in the low-density lipoprotein fraction of plasma, and the electrophoretic mobility of these lipoproteins is greatly increased.

MeSH Terms

Cholesterol Esters/blood Electrophoresis, Agar Gel Female Genes, Recessive Genetic Linkage Humans Ichthyosis/blood,genetics Lipoproteins, LDL/blood Steryl-Sulfatase Sulfatases/deficiency Sulfates X Chromosome

Chemicals

Cholesterol Esters Lipoproteins, LDL Sulfates Sulfatases Steryl-Sulfatase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Epstein E H

Krauss R M

Shackleton C H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6945674

Published

1981-11-06

Pages

659-60

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIADDK NIH HHS · AM 28069 · United States

NHLBI NIH HHS · HL 18574 · United States

NCRR NIH HHS · RR 00719 · United States

External Links

PubMed source DOI: 10.1126/science.6945674 View journal details

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X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein.

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