Microfilament or microtubule assembly or disassembly against a force.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 9 ·1981-09-00 ·Pages 5613-7

Hill TL

Abstract

Microtubules (tubulin) or bundles of microfilaments (actin) are thought to cause movement, in some instances, by disassembly or assembly of subunits. Possible examples are the pulling of a chromosome toward a pole in mitosis (anaphase) or the deformation of a cell membrane to change the shape of a cell. This paper examines the relevant elementary bioenergetic considerations when assembly or disassembly of an aggregate occurs against a resisting force. The problem is considered, in the first section, without NTPase activity. Sickle cell hemoglobin aggregation in vivo is an example. In the second section, the tubulin GTPase and actin ATPase activities are included in the analysis.

MeSH Terms

Actins/physiology Adenosine Triphosphate/metabolism Biomechanical Phenomena Cell Movement Cytoskeleton/physiology Guanosine Triphosphate/metabolism Microtubules/physiology Tubulin/physiology

Chemicals

Actins Tubulin Guanosine Triphosphate Adenosine Triphosphate

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hill T L

References (8)

8 references, click to expand

Head to tail polymerization of actin.
J Mol Biol. 1976 Nov;108(1):139-50 PMID: 1003481
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning.
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3466-70 PMID: 269406
Biochemistry of actomyosin-dependent cell motility (a review).
Proc Natl Acad Sci U S A. 1978 Feb;75(2):588-99 PMID: 147464
Theoretical aspects of translocation on DNA: adenosine triphosphatases and treadmilling binding proteins.
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4796-800 PMID: 6272273
Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo.
J Cell Biol. 1980 Jul;86(1):330-4 PMID: 6893454
Bioenergetic aspects and polymer length distribution in steady-state head-to-tail polymerization of actin or microtubules.
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4803-7 PMID: 6933529
Steady-state head-to-tail polymerization of actin or microtubules. II. Two-state and three-state kinetic cycles.
Biophys J. 1981 Mar;33(3):353-71 PMID: 6452913
Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly.
J Cell Biol. 1980 Jan;84(1):141-50 PMID: 7350166

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.78.9.5613

Published

1981-09-00

Pages

5613-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC348804

Subset

External Links

PubMed source DOI: 10.1073/pnas.78.9.5613 PMC Full Text View journal details

Analysis Services

Microfilament or microtubule assembly or disassembly against a force.

Contact

WeChat Official Account