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PMID: 6951201 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rejection of stable cultured allografts by active or passive (adoptive) immunization.

Vesole DH, Dart GA, Talmage DW

Abstract

Injection of live lymphoid cells of donor strain or immune cells of recipient strain resulted in rejection of previously stable cultured mouse thyroid allografts. The results are interpreted to indicate that a cultured graft is relatively ineffective in activating recipient lymphocytes but is capable of maintaining them in an activated state and serving as a target for them once they are activated.

MeSH Terms
Animals Cells, Cultured Graft Rejection Immunization Immunization, Passive Lymph Nodes/immunology Lymphocytes/immunology Mice Spleen/immunology Time Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vesole D H
Dart G A
Talmage D W
References (7)
7 references, click to expand
  1. Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection.
    Science. 1976 Jan 30;191(4225):385-8 PMID: 1082167
  2. Effect of organ culture on the survival of thyroid allografts in mice.
    Transplantation. 1976 Aug;22(2):138-49 PMID: 61634
  3. A search for the optimum conditions for culturing allografts before transplantation.
    Clin Immunol Immunopathol. 1980 Mar;15(3):314-7 PMID: 7371224
  4. Allo-responsive T lymphocytes and their differentiation markers.
    Fed Proc. 1981 Apr;40(5):1466-70 PMID: 6971234
  5. Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.
    J Exp Med. 1981 May 1;153(5):1044-57 PMID: 7019377
  6. Reversal diabetes by islet transplantation: vulnerability of the established allograft.
    Science. 1981 Sep 11;213(4513):1261-2 PMID: 6791285
  7. Active suppression in the maintenance of pancreatic islet allografts.
    Transplantation. 1981 Aug;32(2):156-8 PMID: 6794197
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1982-03-00
Pages
1626-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346028
Subset
IM
Grants
NIAID NIH HHS · AI03047 · United States
NIAID NIH HHS · AI07035 · United States
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