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PMID: 6964403 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Sleep-promoting effects of muramyl peptides.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 19 ·1982-10-00 ·Pages 6102-6

Krueger JM, Pappenheimer JR, Karnovsky ML

Abstract

A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.

MeSH Terms

Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives,pharmacology Animals Body Temperature/drug effects Brain/drug effects,physiology Cats Kinetics Rabbits Sleep/drug effects Structure-Activity Relationship

Chemicals

Acetylmuramyl-Alanyl-Isoglutamine N-acetylmuramyl-alanyl-isoglutaminyl-lysine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Krueger J M

Pappenheimer J R

Karnovsky M L

References (12)

12 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.79.19.6102

Published

1982-10-00

Pages

6102-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC347061

Subset

Grants

NCRR NIH HHS · RR-5366 · United States

External Links

PubMed source DOI: 10.1073/pnas.79.19.6102 PMC Full Text View journal details

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