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PMID: 6965686 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 124 ·No. 3 ·1980-03-00 ·Pages 1100-5

Russell JH, Masakowski VR, Dobos CB

Abstract

The pattern of progressive release of cytosolic (52Cr) and nuclear (125IUdR) labels from normal or tumor cells being lysed by CTL is strikingly different from the pattern observed when similar cells are lysed by Ab + C or hypotonic shock. We propose that these differences reflect physiologic differences in the lytic events associated with Ab + C- and CTL-mediated cell death.

MeSH Terms

Animals Antibodies/physiology Antilymphocyte Serum/pharmacology Chromium Radioisotopes Complement System Proteins/physiology Cytotoxicity, Immunologic H-2 Antigens Hypotonic Solutions Idoxuridine Iodine Radioisotopes Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Neoplasms, Experimental/immunology Rabbits T-Lymphocytes/physiology

Chemicals

Antibodies Antilymphocyte Serum Chromium Radioisotopes H-2 Antigens Hypotonic Solutions Iodine Radioisotopes Complement System Proteins Idoxuridine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Russell J H

Masakowski V R

Dobos C B

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1980-03-00

Pages

1100-5

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

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Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement.

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