Role of a cefoxitin-inducible beta-lactamase in a case of breakthrough bacteremia.

Journal of clinical microbiology ·Vol. 12 ·No. 4 ·1980-10-00 ·Pages 517-20

Beckwith DG, Jahre JA

Abstract

Development of resistance during therapy with cefamandole contributes to treatment failure. A simple cefoxitin disk test was recently described which detects a cefamandole-active inducible beta-lactamase not otherwise detectable with cefamandole as the inducer. A case of breakthrough Enterobacter bacteremia due to selection of a resistant subpopulation is reported in an immunocompromised patient. The use of this simple disk test in selected clinical cases is advocated.

MeSH Terms

Adult Bacteria/drug effects Cefamandole/pharmacology,therapeutic use Cefoxitin Cephalosporins/pharmacology Enterobacter/drug effects,enzymology Enterobacteriaceae/drug effects Enterobacteriaceae Infections/drug therapy Enzyme Induction Humans Male Microbial Sensitivity Tests/methods beta-Lactamases/biosynthesis

Chemicals

Cephalosporins Cefamandole Cefoxitin beta-Lactamases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Beckwith D G

Jahre J A

References (14)

14 references, click to expand

Persistent gram-negative bacteremia. Observations in twenty patients.
Am J Surg. 1973 Jun;125(6):705-17 PMID: 4575682
Gram-negative bacteremia of long duration. Clinical study of 29 patients.
Cleve Clin Q. 1973 Summer;40(2):47-56 PMID: 4577963
Susceptibility of Enterobacter to cefamandole: evidence for a high mutation rate to resistance.
Antimicrob Agents Chemother. 1976 Jun;9(6):970-4 PMID: 938026
Simultaneous antibiotic levels in "breakthrough" gram-negative rod bacteremia.
Am J Med. 1976 Oct;61(4):493-7 PMID: 788512
Substrate inhibition of beta-lactamases, a method for predicting enzymatic stability of cephalosporins.
Antimicrob Agents Chemother. 1976 Sep;10(3):470-5 PMID: 984790
Cefamandole nafate therapy of respiratory tract, skin, and soft tissue infections in 74 patients.
J Infect Dis. 1978 May;137 Suppl:S110-S118 PMID: 418126
Cefamandole in the treatment of infections due to Enterobacter and indole-positive Proteus.
J Infect Dis. 1978 May;137 Suppl:S125-S132 PMID: 649997
Carbenicillin plus cefamandole in the treatment of infections in patients with cancer.
J Infect Dis. 1978 May;137 Suppl:S139-S143 PMID: 649998
Efficacy and safety of cefamandole plus either gentamicin or tobramycin in therapy of severe gram-negative bacterial infections.
J Infect Dis. 1978 May;137 Suppl:S144-S149 PMID: 349093
Comparison of BL-S786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice.
J Antibiot (Tokyo). 1978 Apr;31(4):363-72 PMID: 306989
Standardization of the Analytab Enteric (API 20E) system to increase accuracy and reproducibility of the test for biotype characterization of bacteria.
J Clin Microbiol. 1978 Jul;8(1):46-9 PMID: 353072
Lack of correlation between beta-lactamase production and susceptibility to cefamandole or cefoxitin among spontaneous mutants of Enterobacteriaceae.
Antimicrob Agents Chemother. 1979 Jan;15(1):14-9 PMID: 311615
Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases.
Antimicrob Agents Chemother. 1979 Jun;15(6):792-7 PMID: 314270
Simultaneous recovery of ampicillin-sensitive and ampicillin-resistant H. influenzae from blood.
J Pediatr. 1980 May;96(5):954 PMID: 6965981

Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.12.4.517-520.1980

Published

1980-10-00

Pages

517-20

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC273627

Subset

External Links

PubMed source DOI: 10.1128/jcm.12.4.517-520.1980 PMC Full Text View journal details

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Role of a cefoxitin-inducible beta-lactamase in a case of breakthrough bacteremia.

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