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PMID: 6976417 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.

The Journal of experimental medicine ·Vol. 155 ·No. 1 ·1982-01-01 ·Pages 52-60

Owen FL, Spurll GM, Panageas E

Abstract

Tthyd is an alloantigen coded for by a gene(s) near the immunoglobulin locus on chromosome 12 in the mouse. This T cell-specific antigen may be the third member of a family of antigen receptors on T cells encoded by a cluster of genes in the IgT-C region. This antigen is preferentially expressed on thymocytes in contrast to Tindd or Tsud that are expressed on peripheral T cells. The hypothesis that T cell receptors undergo a switch in surface isotype upon maturation is discussed.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Isoantigens/genetics,immunology Lymph Nodes/immunology Mice Mice, Inbred A Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Phenotype Receptors, Antigen, T-Cell/genetics,immunology Recombination, Genetic Spleen/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Isoantigens Receptors, Antigen, T-Cell
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Owen F L
Spurll G M
Panageas E
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27 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.155.1.52
Published
1982-01-01
Pages
52-60
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186581
Subset
IM
Grants
NIAID NIH HHS · AI-15262-4 · United States
NIAID NIH HHS · AI-17442-01 · United States
External Links
PubMed source DOI: 10.1084/jem.155.1.52 PMC Full Text View journal details
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