Epithelioid granuloma formation requiring no T-cell function.

The American journal of pathology ·Vol. 106 ·No. 2 ·1982-02-00 ·Pages 165-70

Tanaka A, Emori K, Nagao S, Kushima K, Kohashi O, Saitoh M, Kataoka T

Abstract

Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in-oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.

MeSH Terms

Acetylmuramyl-Alanyl-Isoglutamine Animals DNA/biosynthesis Female Granuloma/etiology,pathology Lymph Nodes/pathology Male Neutrophils/pathology Rats T-Lymphocytes/immunology

Chemicals

Acetylmuramyl-Alanyl-Isoglutamine DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Tanaka A

Emori K

Nagao S

Kushima K

Kohashi O

Saitoh M

Kataoka T

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29 references, click to expand

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Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1982-02-00

Pages

165-70

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC1916186

Subset

External Links

PubMed source PMC Full Text View journal details

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Epithelioid granuloma formation requiring no T-cell function.

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