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PMID: 6980708 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle.

Cellular and molecular neurobiology ·Vol. 1 ·No. 2 ·1981-06-00 ·Pages 209-30

Schofield GG, Warnick JE, Albuquerque EX

Abstract

The effects of the muscarinic antagonist quinuclidinyl benzilate (QNB) on transmission at the frog sartorius neuromuscular junction have been examined. QNB decreases endplate potential (EPP) amplitude without affecting miniature endplate (MEPP) frequency or resting potential. QNB also increased the latency of the EPP and the nerve terminal spike in a frequency dependent fashion, suggesting the site of action is the unmyelinated nerve terminal. Since the rate and amplitude of muscle action are potentials decreased it is likely that QNB causes a blockade of electrically excitable sodium channels; the agent also blocks ionic channels associated with nicotinic acetylcholine receptors. It is possible that these effects of QNB may explain some of the behavioral disturbances produced by its administration.

MeSH Terms
Animals Evoked Potentials/drug effects Kinetics Membrane Potentials/drug effects Motor Endplate/drug effects,physiology Muscles/drug effects,physiology Neuromuscular Junction/physiology Quinuclidines/pharmacology Quinuclidinyl Benzilate/pharmacology Rana pipiens
Chemicals
Quinuclidines Quinuclidinyl Benzilate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schofield G G
Warnick J E
Albuquerque E X
References (33)
33 references, click to expand
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Article Info
Journal
Cellular and molecular neurobiology
Abbr.
Cell Mol Neurobiol
ISSN
0272-4340
DOI
10.1007/BF00710720
Published
1981-06-00
Pages
209-30
Language
English
Region
United States
NLM ID
8200709
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00710720 View journal details
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