Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.

Annals of the rheumatic diseases ·Vol. 41 ·No. 4 ·1982-08-00 ·Pages 403-4

Schiff B, Mizrachi Y, Orgad S, Yaron M, Gazit E

Abstract

Forty-nine Israeli Jewish patients with rheumatoid arthritis (RA) were studied for their HLA A, B, C, DR antigen frequency. A significant increase in HLA Aw31 and HLA DR1 was observed (p less than 5.10(-5) and p less than 5.10(-3) respectively). 45% of Aw31 positive patients were sero-negative for rheumatoid factor, while most HLA DR1 positive individuals were seropositive. DR5 was found to be significantly decreased (p less than 5.10(-4)). Contrary to previous reports, DRw4 was found to be within the range of antigen frequency of the controls (34.7% vs. 32%). It is suggested that in our population of patients Aw31 and DR1 and not DR4 are highly associated with adult onset of RA.

MeSH Terms

Aged Arthritis, Rheumatoid/immunology Female HLA Antigens/analysis HLA-A Antigens HLA-DR1 Antigen Histocompatibility Antigens Class II/analysis Humans Male Middle Aged

Chemicals

HLA Antigens HLA-A Antigens HLA-A31 antigen HLA-DR1 Antigen Histocompatibility Antigens Class II

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Schiff B

Mizrachi Y

Orgad S

Yaron M

Gazit E

References (9)

9 references, click to expand

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Mixed lymphocyte cultures in rheumatoid arthritis.
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HLA antigen in Jewish patients with juvenile diabetes mellitus.
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Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis.
J Clin Invest. 1980 Mar;65(3):629-42 PMID: 6766468
Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.
N Engl J Med. 1978 Apr 20;298(16):869-71 PMID: 147420
HLA-DRw4 and rheumatoid arthritis.
Lancet. 1979 Mar 10;1(8115):549 PMID: 85123
HLA-D and DR determinants in rheumatoid arthritis.
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Article Info

Journal

Annals of the rheumatic diseases

Abbr.

Ann Rheum Dis

ISSN

0003-4967

DOI

10.1136/ard.41.4.403

Published

1982-08-00

Pages

403-4

Language

English

Region

England

NLM ID

0372355

PMCID

PMC1000958

Subset

External Links

PubMed source DOI: 10.1136/ard.41.4.403 PMC Full Text View journal details

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Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.

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