Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.

Science (New York, N.Y.) ·Vol. 207 ·No. 4426 ·1980-01-04 ·Pages 71-3

Yoshida N, Nussenzweig RS, Potocnjak P, Nussenzweig V, Aikawa M

Abstract

Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.

MeSH Terms

Animals Antibodies Antigens, Surface Clone Cells/immunology Hybrid Cells/immunology Malaria/immunology Membrane Proteins/immunology Mice Molecular Weight Myeloma Proteins/immunology Neoplasms, Experimental/immunology Plasmacytoma/immunology Plasmodium berghei/immunology Spleen/immunology

Chemicals

Antibodies Antigens, Surface Membrane Proteins Myeloma Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Yoshida N

Nussenzweig R S

Potocnjak P

Nussenzweig V

Aikawa M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6985745

Published

1980-01-04

Pages

71-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6985745 View journal details

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Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.

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