Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord.

Cell and tissue research ·Vol. 192 ·No. 3 ·1978-09-26 ·Pages 423-35

Buijs RM

Abstract

Vasopressin and oxytocin pathways were specifically localized in glutaraldehyde-paraformaldehyde fixed rat brains, with the use of the unlabelled antibody enzyme method and purification of the first antiserum. Vasopressin and oxytocin containing pathways were traced from the paraventricular nucleus towards the dorsal and ventral hippocampus, the nuclei of the amygdala, substantia nigra and substantia grisea, nucleus tractus solitarius, nucleus ambiguus and to the substantia gelatinosa of the spinal cord. In addition, a vasopressin containing pathway between the suprachiasmatic nucleus and the lateral habenular nucleus was demonstrated. The possible nature (axons or dendrites) and role of these extrahypothalamic fibres is discussed in relation to water balance, milk ejection and avoidance behaviour.

MeSH Terms

Animals Hypothalamus/anatomy & histology Limbic System/anatomy & histology Male Medulla Oblongata/anatomy & histology Nerve Fibers/anatomy & histology Neural Pathways Neurosecretory Systems/anatomy & histology Oxytocin/metabolism Paraventricular Hypothalamic Nucleus/anatomy & histology Rats Spinal Cord/anatomy & histology Supraoptic Nucleus/anatomy & histology Vasopressins/metabolism

Chemicals

Vasopressins Oxytocin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Buijs R M

References (24)

24 references, click to expand

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Article Info

Journal

Cell and tissue research

Abbr.

Cell Tissue Res

ISSN

0302-766X

DOI

10.1007/BF00212323

Published

1978-09-26

Pages

423-35

Language

English

Region

Germany

NLM ID

0417625

Subset

External Links

PubMed source DOI: 10.1007/BF00212323 View journal details

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Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord.

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