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PMID: 699047 Published · ppublish English Journal Article

Recessive male-determining genes.

Cell ·Vol. 15 ·No. 1 ·1978-09-00 ·Pages 279-81

Wachtel SS, Basrur P, Koo GC

Abstract

The autosomal dominant gene polled (P) causes hornlessness in goats. Chromosomal females (XX) that are P/P homozygotes develop testes or ovotestes. Thus with respect to its testis-determining properties, P or a closely linked gene acts as an autosomal recessive. Polled intersex goats are H-Y+. This finding is consistent with the view that there may be a cluster of testis-determining H-Y genes on the Y chromosome, and that translocation of a subcritical portion of these genes may generate a recessive mode of sex determination.

MeSH Terms
Animals Disorders of Sex Development/genetics,immunology Female Genes Genes, Recessive Genetic Linkage Goats/genetics H-Y Antigen/genetics Male Mutation Sex Determination Analysis Translocation, Genetic Y Chromosome
Chemicals
H-Y Antigen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wachtel S S
Basrur P
Koo G C
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
Published
1978-09-00
Pages
279-81
Language
English
Region
United States
NLM ID
0413066
Subset
IM
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