A new factor that may control collagen resorption.

Lancet (London, England) ·Vol. 2 ·No. 8033 ·1977-08-13 ·Pages 333-5

Reynolds JJ, Murphy G, Sellers A, Cartwright E

Abstract

Specific collagenases responsible for the initial enzymic step leading to degradation of the collagen fibrils of connective tissues have been found in both latent and active forms. The most important factor controlling the local activity of collagenase extracellularly may be an inhibitor that is synthesised by connective tissues, and it is proposed that latent enzymes are all enzyme-inhibitor complexes.

MeSH Terms

Animals Anura Cattle Chickens Collagen/metabolism Connective Tissue/enzymology,metabolism Culture Media Culture Techniques Enzyme Inhibitors/pharmacology Guinea Pigs Humans Mice Microbial Collagenase/antagonists & inhibitors,biosynthesis Phenylmercuric Acetate/analogs & derivatives,pharmacology Rabbits Swine Trypsin/pharmacology

Chemicals

Culture Media Enzyme Inhibitors Collagen Trypsin Microbial Collagenase Phenylmercuric Acetate

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Reynolds J J

Murphy G

Sellers A

Cartwright E

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(77)91490-8

Published

1977-08-13

Pages

333-5

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(77)91490-8 View journal details

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