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PMID: 7002794 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp.

Infection and immunity ·Vol. 30 ·No. 2 ·1980-11-00 ·Pages 321-4

Adamus G, Mulczyk M, Witkowska D, Romanowska E

Abstract

Active immunization of guinea pigs and rabbits with outer membrane proteins (OMP) isolated from Shigella flexneri 3a and Shigella sonnei phase I protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. Protection was also achieved in rabbits after passive immunization with anti-OMP immune serum. Active immunization with lipopolysaccharide of S. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.

MeSH Terms
Animals Bacterial Proteins/immunology Dysentery, Bacillary/prevention & control Guinea Pigs Immunization Immunization, Passive Keratoconjunctivitis/immunology,microbiology,prevention & control Membrane Proteins/immunology Rabbits Shigella flexneri/immunology
Chemicals
Bacterial Proteins Membrane Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Adamus G
Mulczyk M
Witkowska D
Romanowska E
References (14)
14 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.30.2.321-324.1980
Published
1980-11-00
Pages
321-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC551312
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.30.2.321-324.1980 PMC Full Text View journal details
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