LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective.

Adipose Tissue/metabolism Adult Animals Blood Glucose/metabolism Child, Preschool Deoxyglucose/metabolism Diabetes Mellitus/drug therapy,metabolism Dose-Response Relationship, Drug Humans In Vitro Techniques Insulin/genetics,physiology Insulin Antagonists/blood Insulin Resistance Islets of Langerhans/metabolism Liver/metabolism Monocytes/metabolism Obesity/metabolism Proinsulin/metabolism Receptor, Insulin/drug effects,metabolism Spermine/pharmacology Sulfonylurea Compounds/therapeutic use

Blood Glucose Insulin Insulin Antagonists Sulfonylurea Compounds Spermine Proinsulin Deoxyglucose Receptor, Insulin