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PMID: 7010607 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cadmium-113 nuclear magnetic resonance studies of bovine insulin: two-zinc insulin hexamer specifically binds calcium.

Science (New York, N.Y.) ·Vol. 212 ·No. 4494 ·1981-05-01 ·Pages 560-2

Sudmeier JL, Bell SJ, Storm MC, Dunn MF

Abstract

By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion binding sites.

MeSH Terms
Animals Binding Sites Cadmium Calcium/metabolism Cattle Insulin/metabolism Isotopes Ligands Macromolecular Substances Magnetic Resonance Spectroscopy Protein Conformation Zinc/metabolism
Chemicals
Insulin Isotopes Ligands Macromolecular Substances Cadmium Zinc Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sudmeier J L
Bell S J
Storm M C
Dunn M F
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.7010607
Published
1981-05-01
Pages
560-2
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NCRR NIH HHS · 5S05RR 07010-09 · United States
External Links
PubMed source DOI: 10.1126/science.7010607 View journal details
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