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PMID: 7012632 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Pseudohyphal forms of Cryptococcus neoformans: decreased survival in vivo.

Mycopathologia ·Vol. 73 ·No. 1 ·1981-01-30 ·Pages 57-9

Neilson JB, Fromtling RA, Bulmer GS

Abstract

Three pseudohyphal isolates of Cryptococcus neoformans were inoculated intracranially into mice. Four weeks post-inoculation the animals showed no symptoms of disease and the number of viable cells per brain decreased to zero. Possible roles of pseudohyphal forms of C. neoformans in the immunology and pathogenesis of cryptococcosis are discussed.

MeSH Terms
Animals Brain/microbiology Cryptococcus/growth & development Cryptococcus neoformans/cytology,growth & development,pathogenicity Mice
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Neilson J B
Fromtling R A
Bulmer G S
References (7)
7 references, click to expand
  1. Preliminary studies on a hyphaforming mutant of Cryptococcus neoformans.
    Mycologia. 1966 May-Jun;58(3):383-90 PMID: 5941601
  2. Morphological variations of a hypha-forming strain of Cryptococcus neoformans (Coward strain) in tissues of mice.
    Sabouraudia. 1971 Mar;9(1):10-4 PMID: 4928767
  3. Medium containing trypan blue and antibiotics for the detection of Cryptococcus neoformans in clinical samples.
    Appl Microbiol. 1974 Jan;27(1):38-42 PMID: 4203789
  4. Filamentation and endogenous sporulation in Cryptococcus neoformans.
    Sabouraudia. 1970 Nov;8(3):227-34 PMID: 4099976
  5. Immunization of mice with an avirulent pseudohyphal form of Cryptococcus neoformans.
    Mycopathologia. 1979 Sep 28;68(3):179-81 PMID: 394001
  6. Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga.
    Infect Immun. 1978 Apr;20(1):262-6 PMID: 352931
  7. Kinetics of lymphocyte transformation in mice immunized with viable avirulent forms of Cryptococcus neoformans.
    Infect Immun. 1979 May;24(2):449-53 PMID: 378854
Article Info
Journal
Mycopathologia
Abbr.
Mycopathologia
ISSN
0301-486X
DOI
10.1007/BF00443015
Published
1981-01-30
Pages
57-9
Language
English
Region
Netherlands
NLM ID
7505689
Subset
IM
Grants
NIAID NIH HHS · AI-05022 · United States
External Links
PubMed source DOI: 10.1007/BF00443015 View journal details
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