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PMID: 7014630 Published · ppublish English Comparative Study Journal Article

Comparison of the cell cytoskeleton in migratory and stationary chick fibroblasts.

Journal of muscle research and cell motility ·Vol. 1 ·No. 1 ·1980-03-00 ·Pages 5-14

Badley RA, Couchman JR, Rees DA

Abstract

The organization of the principal cytoskeletal components (actin, tubulin and 10 nm filament protein) have been compared by immunofluorescence microscopy in two populations of chick heart fibroblasts, previously shown to be adapted respectively for rapid, directed migration or adhesion and growth. We find that neither microtubule nor 10 nm filament distributions after significantly during the conversion from the migratory to the stationary state but in contrast there are significant differences in the organization of actin. The stationary cells possess more numerous and thicker stress fibre bundles. The variety of patients observed in the migratory cells are documented and the possible roles of the different components of the cytoskeleton in cell locomotion are discussed.

MeSH Terms
Actins/metabolism Animals Cell Adhesion Cell Movement Cells, Cultured Chick Embryo Cytoskeleton/physiology Fibroblasts/physiology Fluorescent Antibody Technique Microtubules/physiology Tubulin/metabolism
Chemicals
Actins Tubulin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Badley R A
Couchman J R
Rees D A
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32 references, click to expand
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Article Info
Journal
Journal of muscle research and cell motility
Abbr.
J Muscle Res Cell Motil
ISSN
0142-4319
DOI
10.1007/BF00711922
Published
1980-03-00
Pages
5-14
Language
English
Region
Netherlands
NLM ID
8006298
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00711922 View journal details
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