High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 5 ·1981-05-00 ·Pages 3010-4

Matus A, Bernhardt R, Hugh-Jones T

Abstract

The distributions of tubulin and high molecular weight microtubule-associated proteins (HMWPs) in brain were determined by immunoperoxidase histochemistry with specific antisera. Tubulin was found in microtubules of both neurons and glia and both axons and dendrites. HMWPs were found only in neurons where, in all cases examined, they were associated with dendritic microtubules but not those in axons. Both tubulin and HMWPs were also found in postsynaptic densities. These results indicate that brain microtubules vary in chemical composition. The preferential association of HMWPs with dendritic microtubules suggests that they may play a role in distinguishing between dendritic and axonal export routes from the cell body.

MeSH Terms

Animals Brain/ultrastructure Brain Chemistry Cerebellar Cortex/ultrastructure Dendrites/ultrastructure Immunoenzyme Techniques Microscopy, Electron Microtubule-Associated Proteins Microtubules/ultrastructure Nerve Tissue Proteins/analysis Organ Specificity Proteins/analysis Rats Tubulin/analysis

Chemicals

Microtubule-Associated Proteins Nerve Tissue Proteins Proteins Tubulin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Matus A

Bernhardt R

Hugh-Jones T

References (24)

24 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.78.5.3010

Published

1981-05-00

Pages

3010-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC319489

Subset

External Links

PubMed source DOI: 10.1073/pnas.78.5.3010 PMC Full Text View journal details

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High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.

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