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PMID: 7019917 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nature of the G1 phase of the yeast Saccharomyces cerevisiae.

Singer RA, Johnston GC

Abstract

Under conditions that protract the S phase for Saccharomyces cerevisiae without affecting steady-state rates of cell growth or proliferation, there were striking decreases in the length of the G1 period. These decreases were localized in the period between mitosis and the start event that initiates a new cell cycle. We conclude that this major fraction of the G1 period has no functional role in the DNA-division sequence of cell cycle events.

MeSH Terms
Cell Division/drug effects Hydroxyurea/pharmacology Interphase/drug effects Kinetics Mutation Saccharomyces cerevisiae/drug effects,physiology Temperature
Chemicals
Hydroxyurea
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Singer R A
Johnston G C
References (30)
30 references, click to expand
  1. The use of conditional lethal cell cycle mutants for temporal and functional sequence mapping of cell cycle events.
    J Cell Physiol. 1978 Jun;95(3):393-405 PMID: 348711
  2. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation.
    J Mol Biol. 1971 Jul 14;59(1):183-94 PMID: 5283752
  3. [Synthesis of dihydrofolate reductase by synchronized yeast cells. Relationship between DNA replication and the graded time course of enzyme synthesis].
    Eur J Biochem. 1970 Mar 1;13(1):137-41 PMID: 5439076
  4. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis.
    J Mol Biol. 1974 Apr 15;84(3):445-61 PMID: 4618856
  5. Different Chinese hamster cell lines express a G1 period for different reasons.
    Somatic Cell Genet. 1979 Sep;5(5):615-23 PMID: 531733
  6. Macromolecule synthesis in temperature-sensitive mutants of yeast.
    J Bacteriol. 1967 May;93(5):1662-70 PMID: 5337848
  7. Periodic density fluctuation during the yeast cell cycle and the selection of synchronous cultures.
    J Bacteriol. 1970 Dec;104(3):1280-5 PMID: 16559104
  8. Animal cell cycle.
    Annu Rev Biochem. 1978;47:715-50 PMID: 354504
  9. Saccharomyces cerevisiae cell cycle.
    Bacteriol Rev. 1974 Jun;38(2):164-98 PMID: 4599449
  10. Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae.
    J Bacteriol. 1973 Sep;115(3):966-74 PMID: 4580573
  11. Effect of reversible inhibition of deoxyribonucleic acid synthesis on the yeast cell cycle.
    J Bacteriol. 1973 Jan;113(1):263-70 PMID: 4120066
  12. Genetic analysis of the G1 period: isolation of mutants (or variants) with a G1 perior from a Chinese hamster cell line lacking G1.
    Proc Natl Acad Sci U S A. 1978 Jun;75(6):2873-7 PMID: 275858
  13. Cell cycle of Saccharomycescerevisiae in populations growing at different rates.
    Proc Natl Acad Sci U S A. 1977 Sep;74(9):3850-4 PMID: 333447
  14. Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division.
    Exp Cell Res. 1971 Aug;67(2):389-401 PMID: 5097524
  15. Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA.
    Proc Natl Acad Sci U S A. 1976 May;73(5):1664-8 PMID: 775494
  16. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae.
    Exp Cell Res. 1977 Mar 1;105(1):79-98 PMID: 320023
  17. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.
    J Cell Biol. 1977 Nov;75(2 Pt 1):422-35 PMID: 400873
  18. Chromosome replication and the division cycle of Escherichia coli B/r.
    J Mol Biol. 1968 Feb 14;31(3):519-40 PMID: 4866337
  19. Effect of thymine concentration on the replication velocity of DNA in a thymineless mutant of Escherichia coli.
    Nature. 1970 Apr 11;226(5241):126-31 PMID: 4908371
  20. Genetic control of cell division in yeast cultured at different growth rates.
    Nature. 1977 Sep 8;269(5624):145-7 PMID: 333292
  21. Methods for monitoring the growth of yeast cultures and for dealing with the clumping problem.
    Methods Cell Biol. 1975;11:131-68 PMID: 1102845
  22. RNA synthesis and control of cell division in the yeast S. cerevisiae.
    Cell. 1978 Aug;14(4):951-8 PMID: 99247
  23. Regulation of cell size in the yeast Saccharomyces cerevisiae.
    J Bacteriol. 1979 Jan;137(1):1-5 PMID: 368010
  24. The preparation of yeasts for light microscopy.
    Methods Cell Biol. 1975;11:1-22 PMID: 52821
  25. Genetic control of the cell-division cycle in yeast. I. Detection of mutants.
    Proc Natl Acad Sci U S A. 1970 Jun;66(2):352-9 PMID: 5271168
  26. Reversible arrest of haploid yeast cells in the initiation of DNA synthesis by a diffusible sex factor.
    Exp Cell Res. 1973 Jan;76(1):99-110 PMID: 4566314
  27. A unifying model for the G1 period in prokaryotes and eukaryotes.
    Nature. 1979 Jul 5;280(5717):17-9 PMID: 15305577
  28. Genetic control of the cell division cycle in yeast.
    Science. 1974 Jan 11;183(4120):46-51 PMID: 4587263
  29. Protein synthesis and the presence of absence of a measurable G1 in cultured Chinese hamster cells.
    J Cell Physiol. 1980 Sep;104(3):461-7 PMID: 7419616
  30. Genetic analysis of a Chinese hamster cell line lacking a G1 phase.
    Exp Cell Res. 1978 Jun;114(1):69-77 PMID: 658159
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1981-05-00
Pages
3030-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319493
Subset
IM
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