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PMID: 7032542 Published · ppublish ita English Abstract Journal Article

[The kidney in shock. A new experimental method for the induction of controlled shock. I].

Il rene da shock. Nuova tecnica sperimentale per l'induzione dello shock controllato. Nota I.

Bollettino della Societa italiana di biologia sperimentale ·Vol. 57 ·No. 19 ·1981-10-15 ·Pages 1981-4

Colì G, Frascaroli G, Giubilei G, Grillone G, Nanni Costa A, Piccinni L, Pierangeli A, Prandini R

Abstract

In this research we identify a new experimental model to study the shock-kidney, since this complication occurs with discreet frequency during high surgery operation. The model that better reproduce the surgical shock-kidney is the controlled hypovolemic shock. We used for this experiment five pigs of weight between 40 and 50 kg and were studied the following data: Ecg, arterial pressure, central venous pressure, diuresis (by incannulation of both ureters), renal arterial flow, levels of the renin in the renal vein. The measurements were made before, during and after the shock. The hypovolemic shock was induced by removing from carotid artery a sufficient quantity of blood to bring the pressure to 45-50 mmHg. This pressure level was kept constant for 120 min and then was reported to normal level by introducing the blood previously removed. During the experiment no kind of drugs were used.

MeSH Terms
Animals Blood Pressure Kidney/blood supply,physiopathology Regional Blood Flow Renin/blood Shock/physiopathology Swine
Chemicals
Renin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Colì G
Frascaroli G
Giubilei G
Grillone G
Nanni Costa A
Piccinni L
Pierangeli A
Prandini R
Article Info
Journal
Bollettino della Societa italiana di biologia sperimentale
Abbr.
Boll Soc Ital Biol Sper
ISSN
0037-8771
Published
1981-10-15
Pages
1981-4
Language
ita
Region
Italy
NLM ID
7506962
Subset
IM
External Links
PubMed source
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