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PMID: 7034642 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin.

Antimicrobial agents and chemotherapy ·Vol. 20 ·No. 6 ·1981-12-00 ·Pages 800-2

Martinelli R, Lopes AA, de Oliveira MM, Rocha H

Abstract

Twenty-two adult patients with urinary tract infections caused by penicillin-resistant bacteria completed treatment with amoxicillin alone or amoxicillin plus clavulanic acid in a randomized double-blind clinical trial. Of the 13 patients treated with amoxicillin plus clavulanic acid, the absence of bacteriuria within 7 days of therapy was observed in 85%, as compared with only 25% of the 8 patients receiving amoxicillin only. There were no significant side effects nor any clinical, biochemical, or hematological abnormalities related to either treatment. It was concluded that the combination of clavulanic acid and amoxicillin could be useful in the treatment of uncomplicated urinary tract infection caused by penicillin-resistant bacteria.

MeSH Terms

Amoxicillin/adverse effects,therapeutic use Anti-Bacterial Agents/adverse effects,therapeutic use Clavulanic Acid Clinical Trials as Topic Double-Blind Method Drug Therapy, Combination Female Humans Lactams/adverse effects,therapeutic use Male Middle Aged Penicillin Resistance Penicillins/therapeutic use Urinary Tract Infections/drug therapy

Chemicals

Anti-Bacterial Agents Lactams Penicillins Clavulanic Acid Amoxicillin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Martinelli R

Lopes A A

de Oliveira M M

Rocha H

References (10)

10 references, click to expand

Antibiotic susceptibility testing by a standardized single disk method.
Am J Clin Pathol. 1966 Apr;45(4):493-6 PMID: 5325707
Relapse and reinfection in chronic bacteriuria. II. The correlation between site of infection and pattern of recurrence in chronic bacteriuria.
N Engl J Med. 1968 Feb 22;278(8):422-7 PMID: 4965965
Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.
Antimicrob Agents Chemother. 1977 May;11(5):852-7 PMID: 879738
Sodium clavulanate potentiation of cephalosporin activity against clinical isolates of cephalothin-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 1978 Jul;14(1):118-25 PMID: 356723
THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS.
Medicine (Baltimore). 1965 Jan;44:1-36 PMID: 14264351
[Kinetics of beta-lactamase inhibition by clavulanic acid].
Biochim Biophys Acta. 1978 Oct 12;526(2):572-9 PMID: 363163
The inhibition of staphylococcal beta-lactamase by clavulanic acid.
Biochem J. 1979 Apr 1;179(1):67-76 PMID: 38773
In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin.
J Antimicrob Chemother. 1980 Jul;6(4):455-70 PMID: 6968746
In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin.
Antimicrob Agents Chemother. 1978 Mar;13(3):389-93 PMID: 122520
Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli.
Antimicrob Agents Chemother. 1978 Aug;14(2):224-7 PMID: 308792

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.20.6.800

Published

1981-12-00

Pages

800-2

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC181801

Subset

External Links

PubMed source DOI: 10.1128/AAC.20.6.800 PMC Full Text View journal details

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Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin.

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