Home LiteratureArticle Details
PMID: 7039332 Published · ppublish English Journal Article Review

Chemical carcinogenesis: a biologic perspective.

The American journal of pathology ·Vol. 106 ·No. 2 ·1982-02-00 ·Pages 271-96

Farber E

Abstract

暂无摘要

MeSH Terms
Animals Carcinogens/metabolism,pharmacology Cell Line DNA Repair/drug effects,radiation effects Diet/adverse effects Drug-Related Side Effects and Adverse Reactions Humans Liver/metabolism Liver Neoplasms/chemically induced,metabolism Models, Biological Neoplasms/chemically induced Neoplasms, Experimental/chemically induced Organ Culture Techniques Skin Neoplasms/etiology Ultraviolet Rays/adverse effects
Chemicals
Carcinogens
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Farber E
References (106)
106 references, click to expand
  1. In vitro cell transformation by x-irradiation.
    Nature. 1966 Apr 16;210(5033):276-8 PMID: 5954564
  2. Effect of colostomy on experimentally produced neoplasms of the colon of the rat.
    Cancer. 1967 Sep;20(9):1466-72 PMID: 6038392
  3. Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.
    Cancer Res. 1967 Sep;27(9):1702-11 PMID: 4293077
  4. In vitro malignant transformation by methylcholanthrene of the progeny of single cells derived from C3H mouse prostate.
    Proc Natl Acad Sci U S A. 1970 Jan;65(1):219-25 PMID: 5263752
  5. Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
    Br J Exp Pathol. 1970 Dec;51(6):587-90 PMID: 5493138
  6. Probable clonal genesis of cellular islands induced in rat liver by diethylnitrosamine.
    Eur J Cancer. 1971 Aug;7(4):369-71 PMID: 4255111
  7. Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing?
    Adv Cancer Res. 1972;16:181-234 PMID: 4563044
  8. Chemical carcinogenesis in transposed intestinal segments.
    Cancer Res. 1973 Mar;33(3):536-41 PMID: 4689902
  9. A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylaminoazobenzene.
    Cancer Res. 1973 May;33(5):1119-28 PMID: 4349935
  10. Carcinogenesis--cellular evolution as a unifying thread: Presidential address.
    Cancer Res. 1973 Nov;33(11):2537-50 PMID: 4594098
  11. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.
    Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43 PMID: 4522778
  12. The function and mechanism of promoters of carcinogenesis.
    CRC Crit Rev Toxicol. 1974 Jan;2(4):419-43 PMID: 4822436
  13. Cancer, differentiation and embryonic antigens: some central problems.
    Adv Cancer Res. 1974;19(0):105-65 PMID: 4604182
  14. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats.
    J Natl Cancer Inst. 1974 Oct;53(4):1093-7 PMID: 4427390
  15. Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
    Eur J Cancer. 1975 Mar;11(3):145-54 PMID: 124252
  16. Requirement for cell replication in the fixation and expression of the transformed state in mouse cells treated with 4-nitroquinoline-1-oxide.
    Int J Cancer. 1974 Dec 15;14(6):736-42 PMID: 4463168
  17. Mutation selection and the natural history of cancer.
    Nature. 1975 May 15;255(5505):197-200 PMID: 1143315
  18. Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence.
    Toxicol Appl Pharmacol. 1975 Mar;31(3):325-51 PMID: 238307
  19. Report of a workshop on classification of specific hepatocellular lesions in rats.
    Cancer Res. 1975 Nov;35(11 Pt 1):3214-23 PMID: 171067
  20. Effect of ascorbic acid on rectal polyps of patients with familial polyposis.
    Surgery. 1975 Nov;78(5):608-12 PMID: 1188603
  21. Immunodepression and malignancy.
    Adv Cancer Res. 1975;22:261-422 PMID: 766581
  22. Tumor progression and homeostasis.
    Adv Cancer Res. 1976;23:203-36 PMID: 775933
  23. Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.
    Cancer Res. 1976 Jul;36(7 PT 2):2544-54 PMID: 132270
  24. Early proliferative changes in intestinal cells.
    Cancer Res. 1976 Jul;36(7 PT 2):2665-8 PMID: 1277172
  25. The clonal evolution of tumor cell populations.
    Science. 1976 Oct 1;194(4260):23-8 PMID: 959840
  26. The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
    Cancer Res. 1976 Nov;36(11 Pt 1):3879-87 PMID: 975037
  27. Prolactin and murine mammary tumorigenesis: a review.
    Cancer Res. 1977 Apr;37(4):951-63 PMID: 191183
  28. Excision of O6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-Nitrosourea.
    Chem Biol Interact. 1977 Mar;16(3):325-33 PMID: 862133
  29. The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
    Cancer Res. 1977 Aug;37(8 Pt 2):2943-9 PMID: 872124
  30. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.
    Cancer Res. 1977 Sep;37(9):3238-42 PMID: 884672
  31. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
    Am J Pathol. 1977 Sep;88(3):595-618 PMID: 18937
  32. Diet and cancer of the colon.
    Curr Concepts Nutr. 1977;6:55-71 PMID: 604018
  33. The cellular origin of chemically induced tumours.
    J Cell Sci. 1978 Feb;29:249-69 PMID: 627606
  34. Inhibitors of chemical carcinogenesis.
    Adv Cancer Res. 1978;26:197-226 PMID: 204165
  35. Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.
    Cancer Res. 1978 Jun;38(6):1479-96 PMID: 348302
  36. Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1334-8 PMID: 418410
  37. Tumor initiation and promotion.
    Int Rev Exp Pathol. 1978;18:137-98 PMID: 149093
  38. Initiation of chemical carcinogenesis requires cell proliferation.
    Nature. 1978 Sep 7;275(5675):60-2 PMID: 683342
  39. Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin.
    Science. 1978 Sep 22;201(4361):1141-2 PMID: 684434
  40. Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment.
    Nature. 1978 Sep 14;275(5676):130-2 PMID: 567748
  41. Nuclear metabolism of polycyclic hydrocarbons and interaction of polycyclic hydrocarbons with nuclear components.
    Adv Enzyme Regul. 1977 Oct 3-4;16:347-61 PMID: 616772
  42. Cancer: somatic-genetic considerations.
    Adv Cancer Res. 1978;28:1-29 PMID: 360794
  43. Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
    Cancer Res. 1978 Dec;38(12):4450-7 PMID: 31235
  44. Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment.
    J Environ Pathol Toxicol. 1978 Sep-Oct;2(1):21-8 PMID: 722222
  45. Pathology of prenatal diethylstilbestrol exposure.
    Pathol Annu. 1978;13 Pt 1:201-16 PMID: 364384
  46. Formation and removal of specific acetylaminofluorene-DNA adducts in mouse and human cells measured by radioimmunoassay.
    Cancer Res. 1979 Apr;39(4):1377-81 PMID: 421221
  47. N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.
    J Natl Cancer Inst. 1979 Jun;62(6):1329-39 PMID: 374817
  48. Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
    Cancer Res. 1979 Jul;39(7 Pt 1):2515-21 PMID: 87266
  49. A delayed complication of cancer therapy--cancer.
    J Natl Cancer Inst. 1979 Aug;63(2):275-7 PMID: 287824
  50. Proliferation of rat liver cells in preneoplastic nodules after stimulation of liver growth by xenobiotic inducers.
    Arch Toxicol Suppl. 1979;(2):451-5 PMID: 88929
  51. Dynamics of neoplastic development in carcinogen-exposed tracheal mucosa.
    Cancer Res. 1979 Oct;39(10):4003-10 PMID: 113084
  52. Chemical characterization of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhimurium system.
    Cancer Res. 1979 Sep;39(9):3289-318 PMID: 383284
  53. Chemoprevention of cancer with retinoids.
    Fed Proc. 1979 Oct;38(11):2528-34 PMID: 488376
  54. Short-term tests for carcinogens and mutagens.
    Mutat Res. 1979 Sep;65(3):133-226 PMID: 159413
  55. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens.
    Nature. 1980 Jan 24;283(5745):397-8 PMID: 6766207
  56. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5714-8 PMID: 230490
  57. Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
    Cancer Res. 1980 Apr;40(4):1112-8 PMID: 7357542
  58. Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.
    Cancer Res. 1980 Apr;40(4):1157-64 PMID: 6101993
  59. Distorting the epidemiology of cancer: the need for a more balanced overview.
    Nature. 1980 Mar 27;284(5754):297-300 PMID: 7360265
  60. Transforming activity of DNA of chemically transformed and normal cells.
    Nature. 1980 Apr 3;284(5755):418-21 PMID: 7360280
  61. The epidemiology of cancer.
    Cancer. 1980 May 15;45(10):2475-85 PMID: 7378985
  62. Relationships of bioassay data on chemicals to their toxic and carcinogenic risk for humans.
    J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):431-50 PMID: 6993617
  63. Mammalian cell transformation and mammalian cell mutagenesis in vitro.
    J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):69-87 PMID: 7391738
  64. Evaluating substances for promotion, cofactor effects and synergy in the carcinogenic process.
    J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):89-101 PMID: 7391739
  65. Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.
    Mutat Res. 1980 Jul;76(1):1-50 PMID: 6993936
  66. The sequential analysis of liver cancer induction.
    Biochim Biophys Acta. 1980 May 6;605(2):149-66 PMID: 6994812
  67. The pathogenesis of rat liver cancer caused by chemical carcinogens.
    Biochim Biophys Acta. 1980 May 6;605(2):167-89 PMID: 6249364
  68. The stages of initiation and promotion in hepatocarcinogenesis.
    Biochim Biophys Acta. 1980 May 6;605(2):191-215 PMID: 6249365
  69. The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
    Biochim Biophys Acta. 1980 May 6;605(2):247-304 PMID: 6249366
  70. Environmental influences on human foetal and placental xenobiotic metabolism.
    Eur J Clin Pharmacol. 1980 Jul;18(1):17-24 PMID: 7398743
  71. Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride.
    Science. 1980 Aug 15;209(4458):817-9 PMID: 7403848
  72. The sequential analysis of cancer development.
    Adv Cancer Res. 1980;31:125-226 PMID: 6250325
  73. Tumour promoter alone induces neoplastic transformation of fibroblasts from humans genetically predisposed to cancer.
    Nature. 1979 Dec 6;282(5739):619-21 PMID: 45122
  74. Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.
    J Biol Chem. 1980 Nov 25;255(22):10569-71 PMID: 7000780
  75. Differential repair of O(6)-methylguanine in DNA of rat hepatocytes and nonparenchymal cells.
    Nature. 1980 Nov 13;288(5787):185-41 PMID: 7432520
  76. Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
    Cancer Res. 1980 Oct;40(10):3846-9 PMID: 6108159
  77. Effects of urine and continued exposure to carcinogen on progression of early neoplastic urinary bladder lesions.
    Cancer Res. 1980 Dec;40(12):4524-7 PMID: 7438086
  78. Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters.
    Nature. 1980 Dec 4;288(5790):451-5 PMID: 7442792
  79. Significance of in vivo formation of N-nitroso compounds.
    Oncology. 1980;37(4):223-6 PMID: 7003452
  80. Multiplicity of mammalian microsomal cytochromes P-45.
    Pharmacol Rev. 1979 Dec;31(4):277-95 PMID: 399809
  81. Problems associated with the application of short-term tests for mutagenicity in mass-screening programs.
    Environ Mutagen. 1979;1(3):203-8 PMID: 399909
  82. The cell cycle.
    N Engl J Med. 1981 Feb 19;304(8):453-9 PMID: 6161307
  83. Fallacies of lifestyle cancer theories.
    Nature. 1981 Jan 15;289(5794):127-30 PMID: 7453817
  84. Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay.
    Cancer Res. 1981 Mar;41(3):1091-5 PMID: 7459852
  85. Benzo[a]pyrene metabolism in organ cultures of human endometrium.
    Chem Biol Interact. 1981 Jan;33(2-3):195-205 PMID: 6257404
  86. Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes.
    Ciba Found Symp. 1980;76:261-74 PMID: 6906264
  87. The origin of human cancers.
    Nature. 1981 Jan 29;289(5796):353-7 PMID: 6258076
  88. Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.
    Cancer Res. 1980 Mar;40(3):725-33 PMID: 6110477
  89. Presensitization of human cells with extrinsic signals to induced chemical carcinogenesis.
    Int J Cancer. 1980 Dec 15;26(6):805-12 PMID: 7216548
  90. Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7262-6 PMID: 6938973
  91. Strategies for dietary intervention studies in colon cancer.
    Cancer. 1981 Mar 1;47(5 Suppl):1121-5 PMID: 6263443
  92. Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures.
    Cancer Res. 1981 Jun;41(6):2079-83 PMID: 6113048
  93. Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
    Cancer Res. 1981 Jun;41(6):2096-102 PMID: 6113050
  94. In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2.
    Crit Rev Toxicol. 1981 Jun;8(3):199-234 PMID: 7018838
  95. Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
    Cancer Res. 1981 Sep;41(9 Pt 1):3281-7 PMID: 7020925
  96. Biological and enzymatic events in chemical carcinogenesis.
    Annu Rev Med. 1979;30:25-39 PMID: 400494
  97. Ultrasensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts.
    Carcinogenesis. 1980 May;1(5):455-8 PMID: 7023719
  98. The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
    Gan. 1980 Dec;71(6):832-42 PMID: 7274629
  99. Metabolism of aflatoxin B1, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colon.
    Teratog Carcinog Mutagen. 1980;1(1):3-13 PMID: 6119799
  100. The life and progression of induced skin tumors in mice.
    Br J Cancer. 1953 Sep;7(3):342-51 PMID: 13106200
  101. A speculative review; the probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis.
    Cancer Res. 1954 Aug;14(7):471-7 PMID: 13190523
  102. The carcinogenic effect of aramite in rats. A study of hepatic nodules.
    Cancer. 1960 Sep-Oct;13:1035-46 PMID: 13737205
  103. SOME BIOLOGICAL ASPECTS OF SKIN CARCINOGENISIS.
    Prog Exp Tumor Res. 1964;4:207-50 PMID: 14150247
  104. ETHIONINE CARCINOGENESIS.
    Adv Cancer Res. 1963;7:383-474 PMID: 14153769
  105. FURTHER EXPERIMENTS ON THE CAUSE OF SEQUENTIAL NEOPLASTIC CHANGES. THE EFFECTS OF 20-METHYLCHOLANTHRENE ON TRANSPLANTED EPIDERMAL MOUSE PAPILLOMAS AND THE DERIVATIVE CARCINOMAS.
    J Exp Med. 1964 Aug 1;120:197-222 PMID: 14208248
  106. Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo.
    Biochem J. 1962 Apr;83:114-24 PMID: 14468247
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1982-02-00
Pages
271-96
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916191
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2