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PMID: 7044630 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bw16.

Clinical and experimental immunology ·Vol. 48 ·No. 1 ·1982-04-00 ·Pages 213-7

Mustonen A, Ilonen J, Akerblom HK, Tiilikainen A

Abstract

One hundred and sixty-six unrelated children and adolescents having growth-onset, insulin-dependent diabetes mellitus (IDD) were studied for pancreatic-cytoplasmic islet cell antibodies (ICA) at various times from the diagnosis of the disease. A strong association between HLA antigens A9 and Bw16 and an absence of ICA early in the course of disease was seen. On the other hand B8/Dw3 or B15/Dw4 antigens were not significantly associated with the occurrence of ICA although both these antigens are greatly increased among pediatric IDD patients in northern Finland. The finding of the association of the HLA antigens A9 and Bw16 with ICA-negativity contributes to the evidence for the heterogeneity in the genetic susceptibility to IDD.

MeSH Terms

Adolescent Adult Autoantibodies/biosynthesis,genetics Child Child, Preschool Chromosome Mapping Diabetes Mellitus, Type 1/drug therapy,genetics,immunology Female HLA Antigens/genetics Humans Infant Insulin/therapeutic use Islets of Langerhans/immunology Isoantibodies/genetics Male

Chemicals

Autoantibodies HLA Antigens Insulin Isoantibodies

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mustonen A

Ilonen J

Akerblom H K

Tiilikainen A

References (16)

16 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1982-04-00

Pages

213-7

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1536579

Subset

External Links

PubMed source PMC Full Text View journal details

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An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bw16.

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